عکس بازیگران عکس بازیگران

Vitamin B12 and vitamin B9 (folate) status in Togolese schoolchildren

Ahoefa Vovor, Koko Lawson-Evi, Emile Kou'Santa Amouzou


AIM To determine  the status of vitamin B12 and vitamin B9 (folate) and assess the contribution of these vitamins to anaemia in  Togolese  children.

METHODS Red blood cell parameters, vitamin B12 and vitamin B9 were measured in 155 schoolchildren aged 6-15 years old.

RESULTS Mean values of vitamin B12 and vitamin B9 were 623.83 ± 263.35 pmol/L    and 10.76 ± 4.36 nmol/L respectively. There were no cases of vitamin B12 deficiency. Forty  children had a high level of vitamin B12 >800 pmol/L. Twenty four children were found to be deficient in vitamin B9 but their haematological profile was dominated by hypochromic microcytic anaemia suggesting iron deficiency anaemia rather than megaloblastic anaemia.

CONCLUSION This study suggests that vitamin B12 and vitamin B9 are not important causes of anaemia in Togolese children.


Togo; children; vitamin B12; vitamin B9; anaemia

Full Text:



OMS / UNICEF Joint statement: Focusing on anaemia, towards an integrated approach for effective anaemia control. OMS, 2004. Available at: http://www.who.int/nutrition/publications/micronutrients/WHOandUNICEF_statement_anaemia/en/ (accessed 20 November 2013).

WHO Child Growth Standards 2009. Available at: http://www.who.int/childgrowth/standards/en/ (accessed 20 November 2013)

World Health Organisation. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Available at : http://www.who.int/vmnis/indicators/haemoglobin.pdf (accessed 20 November 2013).

The World Bank Group Togo data profile Source: World Development Indicators database Available at: http://ddp-ext.worldbank.org (accessed 20 January 2012)

Lamparelli RD, Van Der Westhuysen J et al. Nutritional anaemia in 11-year-old schoolchildren in Western Cape. S Afr Med J 1988;73(8):473-6

Galukande M, Jombwe J, Fualal J, R Baingana, Gakwaya A. Reference values for Serum levels of Folic acid and Vitamin B12 in a young adult Ugandan population. African Health Sciences 2011;11(2):240-243

Vanderjagt DJ, Spelman K, Ambe J et al. Folates and vitamin B12 status of adolescents girls in Northern Nigeria. J Natl Med Assoc 2000;92:334-340

Osifo BO, Lukanmbi FA, Boladeoku JO. Reference values for serum folates, erythrocyte folate and serum cobalamine in Nigeria adolescents. Trop Geogr. 1986;38(3):259-64

Guéant JL, Chabi NW, Guéant-Rodriguez RM et al. Environmental influence of the world-wide prevalence of a 776C>G variant in the transcobalamin gene (TCN2). J Med Genet. 2007;44:363-367

Guéant RM, Guéant JL, Debard R et al. Prevalence of methylenetetrahydrofolate reductase 677 and 1298C alleles and folate status: a comparative study in Mexican, West African and European populations. Am J Clin Nutr. 2006;83 (3):701-710

Papandreou D, Mavromichalis I, Makedou A, Rousso I, Arvanitidou M. Total serum homocysteine, folate and vitamin B12 in a Greek school age population. Clinical Nutrition. 2006;25:797–802 (doi:10.1016/j.clnu.2006.02.006)

Bjørke-Monsen AL , Ueland PM. Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. Am J Clin Nutr. 2003;78(1):7-21

Margo G, Baroni Y, Green R, Metz J. Anemia in urban underpriviliged children. Iron, folate and vitamin B12 nutrition. Am J Clin Nutr. 1977;30:947-954.

Amouzou EK, Chabi NW, Adjalla CE et al. High prevalence of hyperhomocysteinemia related to folate deficiency and mutated the 677 C — T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa. Am J Clin Nutr. 2004;79:619-624

میز اداری صندلی مدیریتی صندلی اداری تبلیغات کلیکی میز تلویزیون پاراگلایدر آگهی رایگان محسن چاوشی مسیح و آرش آهنگ جدید دانلود آهنگ جدید خرید اینترنتی عکس بازیگران اطفار عکس بازیگران