عکس بازیگران عکس بازیگران

Causes of lymphocytosis in Abidjan: a preliminary study

Duni SAWADOGO, Mahawa SANGARE-BAMBA, Hermance KASSI-KABRAN, Emma N'DRAMAN, Boidy KOUAKOU

Abstract


AIM We set out to identify the causes of  lymphocytosis in adults in Abidjan by the use  of cytology combined with flow cytometry.

METHODS We recruited 39 patients with  either an organomegaly or a persistent lymphocytosis  above 4 x 109 lymphocytes/L lasting more than 3 months or both presentations. We performed full blood count and immunophenotyping by flow cytometry. We also calculated the Matutes score with the following markers: CD5, CD23, CD22 or CD79b, FMC7 and the surface immunoglobulin (sIg).

RESULTS The mean age of the study patients was 60.28±9.93 with a mean absolute lymphocyte count of 64.5±69.5 109/l. The commonest cause of lymphocytosis in our study was circulating  phases of non-Hodgkin lymphoma followed by chronic lymphocytic leukaemia.

CONCLUSION Patients presenting with lymphocytosis in Abidjan are likely to have chronic B-cell lymphoproliferative disorder.  This finding will inform guidelines for diagnosis and management of chronic lymphoproliferative disorders in Sub-Saharan Africa.


Keywords


Lymphocytosis; Lymphoma; Immunophenotyping; Cote d'Ivoire; Africa.

Full Text:

HTML PDF

References


Schwock J, Geddie WR. Diagnosis of B-Cell Non Hodgkin lymphomas with small-/intermediate sized cells in cytopathology. Pathology Research International 2012:164934. doi: 10.1155/2012/164934/

Van Dongen JJ M, Lhermitte, L, Böttcher S et al. EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes Leukemia 2012;26(9):1908–1975.

Echimane A K, Ahnoux AA, Adoubi I et al. Cancer incidence in Abidjan, Ivory Coast. First results from the registry. Cancer 2000;89(3):653-633.

Matutes E, Owuwu-Ankomah K, Morille R et al. The immunological profile of B cell disorders and proposal of a scoring system for the diagnostic of CLL. Leukemia 1994;8(10):1640-1645.

Moreau EJ, Matutes E, A’Hern RP et al. Improvement of the chronic lymphocytic leukemia scoring system with monoclonal antibody SN 8 (CD 79b). American Journal of Clinical Pathology 1997;108(4):378-382.

Koffi KG, Nanho DC, Tolo A et al. Chronic lymphocytic leukemia in Subsaharan Africa: clinical outcome experience of Côte d'Ivoire. Bull Cancer. 2009;96(9):901-6.

Tanon A, Jaquet A, Ekouevi KD, et al. The Spectrum of Cancers in West Africa: Associations with Human Immunodeficiency Virus. PLoS ONE 2012;7(10):e48108.

Binet JL, Auquier A, Dighiero G et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981;48(1):198-206.

Ibrahim S, Keating M, Do KA, et al. CD 38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001;98(1):181-186.

Dürig J, Naschar M, Schmucker U et al. CD 38 expression is an important prognostic marker in chronic lymphocytic leukaemia. Leukaemia 2002;16(1):30-35.

Prez-Galan P, Dreyling M, Wiestern A. Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic area. Blood 2011;117(1):26-38.

Attia KA, Eholie S, Messou E et al. Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients. World Journal of Hepatology 2012;4(7):218-223.

Cox MC, Aloe-Spiriti MA, Cavalieri E et al. HCV infection, B-cell non-Hodgkin's lymphoma and immunochemotherapy: Evidence and open questions. World J Gastrointestinal Oncology 2012;4(3):46-53.

Van den Brand M, Van Krieken HJM. Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review. Hematologica 2013;98(7):1003-1013.

Sehn LH, Fenske TS and Lapart GG. Follicular lymphoma: prognostic factors, conventional therapies, and hematopietic cell transplantation. Biology of Blood and Marrow Transplantation 2012;18(S1):S82-S91.


میز اداری صندلی مدیریتی صندلی اداری تبلیغات کلیکی میز تلویزیون پاراگلایدر آگهی رایگان محسن چاوشی مسیح و آرش آهنگ جدید دانلود آهنگ جدید خرید اینترنتی عکس بازیگران اطفار عکس بازیگران