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Sickle Cell Anaemia: A survey of associated morbidities in Nigerian Children.

Innocent O. George, Peace I. Opara

Abstract


AIM  Sickle cell anaemia contributes the equivalent of 25% of under 5 deaths in Africa, with up to 16% of such deaths occurring in some West African countries. The aim of this study was to evaluate the prevalence and morbidities associated with sickle cell anaemia at the University of Port Harcourt Teaching Hospital (UPTH), Nigeria.

 

METHODS  This was a retrospective review of case notes of children with sickle cell anaemia (aged 6 months to 18 years) that were seen in the Paediatric Haematology Clinic of UPTH, Port Harcourt, Nigeria from Jan 2009 to December 2009. Data extracted from the patients case notes included age, gender, clinical features, genotype, history of blood transfusion, complications and crises. Descriptive statistics were used to analyse data.

 

RESULTS There were a total of 169 children (aged 0.5-18 years) with sickle cell anaemia during this period. Of these, 92 (57.9%) were males while 77 (42.1%) were females giving a male/female ratio of 1.2:1. The mean age at diagnosis was 2.6 ± 2.1 years. Most 154 (91.1%) of the patients were under 10 years. More than two third of the patients had received blood transfusion ranging from one to seven times. Vaso-occlusive crises in the form of bone pains and hyperhaemolytic crises were the commonest crises while aplastic crises were not encountered. Commonly associated morbidities were malaria 58 (34.3%), dactylitis 43 (25.4%), pneumonia 18 (10.7%) and osteomyelitis 13 (7.1%).

 

CONCLUSION  The study shows that the majority of patients with sickle cell anaemia were l0 years and below, pre supposing that many patients with sickle cell anaemia in our setting are dying in early childhood compared with more developed countries where these patients can live well into their 40s. There is therefore need for surveillance and education at the community level through the primary health-care system so as to increase public awareness of the problem and reduce morbidity and mortality of the affected individuals.


Keywords


Sickle cell anaemia; Survey; Morbidity; Children; Nigeria

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میز اداری صندلی مدیریتی صندلی اداری تبلیغات کلیکی میز تلویزیون پاراگلایدر آگهی رایگان محسن چاوشی مسیح و آرش آهنگ جدید دانلود آهنگ جدید خرید اینترنتی عکس بازیگران اطفار عکس بازیگران